Matthew Perry Died of ‘Acute Effects of Ketamine,’ Autopsy Says

The actor from "Friends," Matthew Perry, sadly passed away due to the strong effects of ketamine, a drug often used for anesthesia and mental health treatments. He was 54. The Los Angeles County medical examiner found that drowning, heart disease, and an opioid also played roles in his death. Perry, known for his struggles with substance abuse, was discovered in a hot tub at his home on October 28. Ketamine, the main cause of Perry's death, is gaining attention as a treatment for depression, anxiety, PTSD, and more, but it's also used recreationally. The autopsy revealed Perry was under ketamine infusion therapy, yet the high levels in his system at the time of death weren't from his last session, which happened more than a week before. The medical experts noted that the amount of ketamine in Perry's blood was like that used in general anesthesia, which can significantly impact heart function and breathing. The FDA has cautioned against using certain forms of this drug for psychiatric conditions. The toxicology report also found manageable levels of buprenorphine, a medication for addiction and pain. Perry's assistant confirmed he was taking this as prescribed. Other sedatives were present, but there was no sign of alcohol, methamphetamine, or cocaine. Details from the day Perry died were revealed in the autopsy report. He played pickleball in the morning, and his assistant found him in the hot tub later that afternoon, unresponsive. Despite efforts to save him, paramedics declared him dead at the scene. Dr. Judy Melinek, a forensic pathologist not involved in the case, highlighted the delays in such investigations, often due to limited resources and specialists in toxicology. This tragic incident brings to light the complexities and potential risks associated with drug use, even under medical supervision, and underscores the importance of careful monitoring and regulation in the use of powerful substances like ketamine.